You know it's coming.

Every year, at least one, maybe two, double-digit-seeded mid-majors get hot, capture the hearts and minds of America, cause mass hysteria, and, ultimately, bust brackets.

So, who are this year's mid-majors most likely to crash the Sweet 16? Here is our pick for the most likely mid-major spoiler in each region.

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UNC Wilmington plays a fundamentally-sound style of basketball, as they're highly efficient at scoring inside the arc and take great care to avoid turnovers. That should make for an intriguing matchup against College Basketball Reference's top-rated defensive squad, Virginia, who usually thrives on taking advantage of other teams' miscues. While UNC Wilmington has won 9 of their last 10 coming into tournament play, Virginia is just 4-5 in their last 9 games.

If UNC Wilmington can upset Tony Bennett's bunch, they'll likely get a crack at a Florida team that is still adapting to the loss of starting center, John Egbunu, to a season-ending ACL injury. Still, Florida, like Virginia, is one of the very best defensive teams in the country.

UNC Wilmington's high-scoring, low-turnover approach, however, gives them a shot of making some noise in the East region. Sophomore C.J. Bryce leads a group of four double-digit scorers capable of punching holes in these stout defenses.

West Region: Florida Gulf Coast

Florida Gulf Coast will forever be synonymous with "Dunk City," after their highlight-packed run to the Sweet 16 as a 15 seed in 2013. The faces have all changed, but don't be surprised if this year's group of Eagles threatens another run at the Sweet 16.

They'll draw a first-round matchup in Orlando with Florida State who, despite putting together a very accomplished season in the ACC, is just 4-4 in their last eight games. Florida State has size, but Gulf Coast is one of the best teams in the country at scoring inside the arc. Florida Gulf Coast also plays a much slower tempo than Florida State. If they can slow Florida State down and dictate game flow, Florida Gulf Coast has got a good chance to limit possessions and increase their odds for playing Cinderella.

If they can pull off the shocking 14-over-3 upset, a matchup with the Maryland/Xavier winner awaits. Those two teams have had their fair share of struggles recently, which could lead many to expect the Eagles to double down if they can get past Florida State.

Midwest Region: Nevada

Nevada checks the box as an appealing March pick with three key traits: they shoot the three-pointer well, they defend the perimeter very well, and they don't turn the ball over.

The Wolf Pack are rolling, having won nine straight on their way to earning the 12 seed in the Midwest region. They should be an interesting matchup for Iowa State, a team who is even better at shooting threes than Nevada is but doesn't defend the arc anywhere near as well as their first-round opponents.

Nevada racked up 10 wins against top-100 RPI teams, more than any team seeded 12 or lower in this year's tournament, so they're no strangers to playing quality opponents. The Wolf Pack doesn't use their bench much, but they don't need to with senior guard Marcus Marshall leading the way with just under 20 points per game.

A win against Iowa State could lead to a matchup with Purdue, who just got bounced in their first game in the Big Ten Tournament.

South Region: Middle Tennessee

Who can forget last year's Middle Tennessee squad who absolutely handled and dismantled 2 seed Michigan State in a way no 15 seed ever should?

The Blue Raiders are back, led again by guard Giddy Potts and big man Reggie Upshaw, and now joined by senior Arkansas transfer and leading scorer JaCorey Williams. Middle Tennessee ripped off a 30-4 season en route to winning the regular season and tournament championships in Conference USA. They are a balanced and experienced team with no glaring weaknesses and plenty of confidence after last year's dominating first-round performance.

This year's Blue Raiders are up to the 12 seed line, where they'll square off with a Minnesota team that's in the NCAA Tournament for the first time under coach Richard Pitino. Minnesota's a great turnaround story, but give Middle Tennessee the edge when it comes to experience.

With a win, Middle Tennessee would face the winner of Butler/Winthrop. Butler is no guarantee to get past Winthrop, given the variability they have experienced this season. Middle Tennessee, with their balance, experience, and draw, looks like the most likely mid-major to keep on dancing into the Sweet 16.