As I already touched on for Vereen, the New Orleans Saints' pass defense is in shambles.
Their schedule-adjusted 0.36 Defensive Passing NEP per play in 2015 was the worst in our database (dating back to 2000), and they gave up top-10 fantasy production to opposing wide receivers.
They didn't make many improvements in the secondary in the offseason and lost Delvin Breaux to injury in Week 1, leaving them starting P.J. Williams and one of two 2016 undrafted free agents (Ken Crawley or De'Vante Harris) at corner.
Victor Cruz didn't play a huge role for the Giants in Week 1, seeing only 4 targets, but he was on the field for 89% of the offensive snaps. He was also efficient, turning those 4 targets into 4 receptions, 34 yards, and 1 touchdown.
With the Giants likely to put up a ton of points in an ideal matchup this week, and sporting a huge 28.5 point implied total, Cruz should be able to thrive even if he doesn't see a major workload.