Chalk:

LeSean McCoy, $8,200 vs San Francisco 49ers - LeSean McCoy finds himself in a dream matchup this week against the San Francisco 49ers and figures to pace the position in ownership. Le'Veon Bell and Lamar Miller won't find themselves far behind in terms of ownership percentage, as this appears set up to be a week to pay up at running back.

Pivots:

Jamaal Charles, $7,100 at Oakland Raiders - There have been conflicting reports regarding Jamaal Charles' usage this week, which should result in most daily fantasy players taking a wait-and-see approach. He logged a full practice on Wednesday, after which he said he felt "110 percent" coming out of the Kansas City Chiefs' bye week. Charles also said he's just as fast as before and that the "training wheels" are coming off this week. Chiefs offensive coordinator Brad Childress expressed a more cautious approach, saying "We'll sprinkle him in where we feel he's most effective."

While a cautious approach certainly is more advisable in cash games, Charles has immense upside in tournaments this week and is likely to go overlooked. His opponent this week, the Oakland Raiders, have given up 4.9 yards per carry (second-worst), emphasized by huge games allowed to Terrance West (21 carries for 113 yards and a touchdown) and DeMarco Murray (16 for 114 and a score with 5 catches for 41 yards). Spencer Ware has certainly carved out a role for himself, but after watching him lose a fumble in three consecutive weeks, it wouldn't be surprising to see the Chiefs give a heavy workload to the all-time leader in yards per carry in a huge divisional battle against the 4-1 Raiders.

Ryan Mathews, $6,500 at Washington Redskins - There was some question about what Ryan Mathews' workload would look like following an ankle injury, but he looked the part of a workhorse in Week 5, totaling 75 yards and a score on 16 touches. He ceded just five carries to other Philadelphia Eagles backs, while surprisingly ranking second on the team in targets.

In Week 6, Mathews will take on a Washington Redskins defense that has allowed a league-worst 5.1 yards per carry this season and ranks sixth-worst in Adjusted Defensive Rushing Net Expected Points (NEP) per play this season. In their three most recent games, they have allowed the likes of Orleans Darkwa, Shane Vereen, Isaiah Crowell, and Terrance West to combine for 335 rushing yards (7.0 yards per attempt) and 3 touchdowns. The Eagles are listed as 2.5-point favorites in this one and should have every opportunity to feed Mathews against Washington's weak run defense.