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Mike Gillislee seems to meander his way on and off waiver wires every other week, but that's largely a byproduct of the Bills' starting running back, LeSean McCoy, being hampered with injuries on a regular basis.
Another injury struck McCoy on Sunday as he left the game with a Jonathan Williams' 5, so in the event McCoy can't play next week, he should shoulder the majority of the load. And with a juicy matchup against the hapless, last-ranked Jaguars' run defense, Gillislee could put up big numbers if the opportunity is there for him.
Grab Gillislee with a speculative add if you've got room on your bench in case McCoy ends up sitting next week. And if he does, Gillislee enters near must-start territory.