High-Cost Option: Atlanta Falcons ($3,900)

The biggest home favorites of the week (-14), Atlanta be taking on a San Francisco offense that isn't afraid to take shots. The 49ers have given up the second-most fumbles this season (11), and Atlanta's defense has multiple sacks in six of their last seven games, averaging 8.6 DK points per game.

San Francisco should be playing in negative game script, allowing the Falcons' pass rushers to pursue Kaepernick relentlessly.

Mid-Cost Option: Buffalo Bills ($3,700)

Taking on the Browns at home, the Bills defense will be a wildly popular selection in terms of ownership, and for good reason.

The Browns are allowing the most sacks (48), quarterback hits (113), and rank top-10 in turnovers (21). The Bills should have little trouble forcing Robert Griffin III into poor mistakes on the road.

Low-Cost Option: Oakland Raiders ($2,700)

An outside-the-box option at defense for those forced to save money, the Raiders could be an interesting defense to deploy. Oakland hasn't scored fewer than seven DK points over their last five games, forcing at least one interception and fumble recovery in each game.

San Diego has allowed the fifth-most fantasy points to opposing D/ST units and leads the league in giveaways (30).

Other Options: Houston D/ST ($3,800), Green Bay D/ST ($3,200)