| Player | Pos | Games | CarAV |
|---|---|---|---|
| Philip Rivers | QB | 180 | 128 |
| Terrell Owens | WR | 219 | 119 |
| DeMarcus Ware | LB | 178 | 100 |
| Walter Jones | T | 180 | 98 |
| Willie Anderson | T | 195 | 90 |
| Cornelius Bennett | LB | 206 | 90 |
| Karlos Dansby | LB | 196 | 79 |
| Julio Jones | WR | 79 | 67 |
| Eric Davis | DB | 188 | 67 |
| Adalius Thomas | LB | 135 | 66 |