In Peyton Manning and the Indianapolis Colts' Super Bowl-winning season, both Marvin Harrison and Reggie Wayne celebrated outstanding individual receiving seasons. The latter racked up 1,310 yards and 9 scores on 86 catches while securing 62.8% of all passes thrown his way.

Wayne earned himself an AV of 17 and possesses the edge over Welker with 9.56 yards per target. Wayne later made a stop at the Pro Bowl, where he would polish his championship ring.