ESPN Ownership: 0.9%
Yahoo Ownership: 4.0%

From a fantasy football standpoint, not many Week 1 injuries have the potential to be as impactful as David Johnson's sprained wrist. There are some mixed reports right now, with some saying that he may miss up to half of the season and other saying there's a chance he doesn't miss any time. But for however many games he misses, he leaves an absolutely massive void in the Arizona Cardinals' offense, having averaged having averaged 18.3 carries and 7.5 targets per game in 2016 and notching 11 carries and 9 targets on Sunday.

Kerwynn Williams doesn't look to be anything special, logging a mere 98 carries over his first four NFL seasons, but he has been very efficient in that limited work, averaging 5.6 yards per attempt and a pretty 0.62 fantasy points per carry.

Williams, if he draws the start in Week 2, also has a great matchup, taking on an Indianapolis Colts team that ranked only 26th in our schedule-adjusted Defensive Rushing Net Expected Points (NEP) per carry in 2016. The Colts allowed 20.6 fantasy points to Los Angeles Rams running back Todd Gurley on Sunday.

Andre Ellington, who actually out-snapped Williams in Week 1, would be worth monitoring, as well.