He's not the most exciting fantasy quarterback around, but Eli Manning does have a pair of games of 20-plus fantasy points to his name this year, and he has tossed multiple touchdowns in four of his last six outings. The two exceptions came against two of the league's top secondaries in the Seattle Seahawks and Denver Broncos.

This week's matchup is much easier for Manning, taking on a San Francisco 49ers team that has allowed at least 15 fantasy points to every quarterback they have faced since Week 2 -- a list that includes poor passers like Drew Stanton.

The Niners rank 24th in numberFire's Adjusted Defensive Passing Net Expected Points (NEP) per play metric, and Manning exploded for a season-high 27.7 fantasy points the last time he faced a bottom-10 pass defense.