Seven NFL teams entered Week 1 with new coaches at the helm. By the end of the week's action, all seven had tasted defeat. This 0-7 start marked the worst record by a group of new head coaches in NFL history.

Matt Nagy and the Chicago Bears came closest to getting a win, as they fell 24-23 to the Green Bay Packers thanks to the wizardry of Aaron Rodgers. The Tennessee Titans and Mike Vrabel lost by one touchdown to the Miami Dolphins in the longest game (time-wise) in NFL history, with the Dolphins prevailing, 27-20. Likewise for Pat Shurmur and the New York Giants, who could muster only 15 points in reply to the 20 of the Jacksonville Jaguars. The Indianapolis Colts led 23-17 after three quarters against the Cincinnati Bengals in Frank Reich's debut, but 17 fourth-quarter points for the visitors doomed his side to defeat.

The four other coaches all lost heavily, and in no small part thanks to the inept performances of their quarterbacks. Matthew Stafford, Derek Carr and Sam Bradford combined for a grand total of one touchdown and eight interceptions in their opening-day beatings. The Detroit Lions were destroyed, 48-17, by the New York Jets, Jon Gruden's second debut for the Oakland Raiders ended in a 33-13 loss to the Los Angeles Rams while Steve Wilks and the Arizona Cardinals slumped to a 24-6 home loss to Washington.

The previous record for most debut losses came in 2001, when six new boys saw their charges defeated. The unlucky six that day were Gregg Williams (Bills), Butch Davis (Browns), Marty Mornhinweg (Lions), Dick Vermeil (Chiefs), Herman Edwards (Jets) and Marty Schottenheimer (Washington).