Yahoo Ownership: 6%

Picking on the Buffalo Bills' offense has been a great strategy this season, as they've given up the most points to fantasy D/STs.

The Houston D/ST put up 18 points (standard scoring) against Buffalo in Week 6, and back in Week 4, the Green Bay D/ST notched 23 points versus the Bills. In all, three of the top-nine best single-week performances from D/STs this campaign have come against Buffalo.

In Week 7, the Bills travel to Indy to face the Colts. Indianapolis has a bad D -- 11th-worst coming into Week 6, per our metrics -- but they've generated 19 sacks and 6 picks through six games.

Regardless of who starts for Buffalo, it's a guy we want to target. Josh Allen has 5 picks this season, Nathan Peterman is Nathan Peterman (2 picks in 12 attempts in relief of Allen on Sunday), and Derek Anderson just got signed last week.

This is a plum spot for the Indy defense, and on a week without many good streaming options, they stand out as the top low-owned D/ST to claim.