If you're in a keeper league in which you are keeping more than a handful of players, make sure it aligns with what type of roster you start. For instance, if you're in a league that starts a ton of wide receivers, you may want to keep a wide receiver because the position is high in demand. In other words, wide receivers will be more costly during the actual draft.
Additionally, if you're in a league that caps the number of keepers you may have and your team is loaded, see if you can trade a few of your 'surplus' keepers for draft picks. Conversely, if you're a team that doesn't love your keeper options, contact a fellow owner who will be losing players back in the pool and see if you can get something you value for mid-round picks.
The lesson learned here: be creative with your roster, and understand the way team's are constructed in your league before making a keeper selection.