The Philadelphia backfield has all the makings for a weekly headache trying to find the highest-scoring fantasy rusher, especially if DeMarco Murray gets his touches limited. Philly ran the sixth-most run plays in the NFL last year, and even a majority share for Murray should leave work behind for Ryan Mathews.

Last year, the Falcons ranked 31st in Adjusted Defensive Rushing NEP and in fantasy points allowed to running backs. Further, the Eagles are three-point road favorites in a game with an over/under of 55. There should be enough scoring and offense to go around, and Mathews figures to have a role in it, making him worth a shot if you're weak at running back.