Karlos Williams is set to step in for LeSean McCoy this week and could very well determine many championship matchups. Taking on our 25th ranked rush defense, he projects as our 12th ranked running back this week.

As bad as the Dallas Cowboys' rush defense has been in real life, they've been just as bad in terms of fantasy production allowed. The Cowboys have allowed the seventh most fantasy points to running backs this season, though they did find success in shutting down Chris Ivory last week.

With the Bills' commitment to the running game -- they average the third most carries in the league -- Williams should be given plenty of opportunities to succeed, providing him with a safe floor and relatively high ceiling.