The bye weeks in Week 6 are much more prohibitive than the ones in Week 5.
Instead of the Raiders and Dolphins sitting the week on the sidelines, it's now the Saints and the Chiefs. So, chances are that you're going to be without a starter in a league or two.
If not, the injury bug might have you down if you have been relying on missed practice on Wednesday. He did, though, throw some passes.
Locker exited his Week 5 contest against the Browns early, but that didn't stop him from putting up 16.6 fantasy points. Locker was 8-of-11 for 79 yards before leaving. He also threw for a touchdown and ran for one as well. In all, he rushed 4 times for 34 yards, realizing his dual-threat potential.
If he gets cleared to play, then he should be in store for a solid performance against the Jaguars, who allow the 30th-most fantasy points to opposing quarterbacks and who currently rank 29th in Adjusted Defensive Passing NEP per play, allowing 0.25 points per pass when adjusted for schedule strength.
Running Back: two ball-carriers rather than four. That doesn't mean Johnson is making the cut, but might sit out Week 6, and that would continue to spell disaster for the Browns secondary.
Wide Receiver: Odell Beckham Jr. (0.8% | 5.4%)
While Beckham missed making his NFL debut for four weeks while battling a hamstring injury, the New York Giants offense learned how to play. Beckham was then able to make his first impression in the NFL by hauling in 4 catches for 44 yards and a touchdown on 5 targets.
At just 5-11, 198 pounds, he doesn't have the typical size of a touchdown-maker, but the matchup is right. While the Eagles rank 15th in Adjusted Defensive Passing NEP per play, they allow the 31st-most points to opposing wide receivers.
Beckham's fantasy potential may ultimately end up being matchup dependent, but there's no reason to shy away from him here against this secondary in a game that has the second-highest over/under (50 points) of the entire NFL weekend.
Tight End: Luke Willson (0.3% | 0.9%)
This recommendation isn't really a result of Wilson's Week 5 performance (3 receptions for 28 yards) but rather the matchup. Before entirely disregarding his Week 5 game, Willson did catch 3 of his 4 targets and played on 63 of Seattle's 67 offensive snaps, so there's reason to believe he'll be on the field in Week 6 against the Cowboys.
The Cowboys are always a target for tight ends, as they allow the most fantasy points to the position. Willson doesn't provide a monstrous ceiling, but he's going to be on the field in a great matchup. The Seahawks have the third-highest total projection based on Vegas odds, so there's a good chance they'll move the ball. Willson could find himself walking into a great day.
If you want less of a deep play, I have two widely-available tight end recommendations in my not-quite-as-deep sleepers slideshow as well.
Flex: Antone Smith (0.7% | 2.8%)
Sometimes in fantasy football, there are guys you hope would see a larger role in a particular offense. For many, Smith is that guy. Dating back to last season, Smith has 16 carries and 8 receptions (24 touches). He has six touchdowns.
That means 25% of his touches result in end zone dances.
While I don't mean to suggest that's sustainable, I do mean to call attention to Smith's big-play potential in case you haven't yet been made fully aware of the Antone show.
The Bears, who Smith faces in Week 6, are the 28th-best rush defense on a per-play basis according to our metrics, and that could be exploitable for a guy who is averaging 16.6 yards per carry (on 16 carries) and 20.8 yards per reception (on 8 receptions) since last year.