Going into the regular season, there's some guys more beat up than others. Or, in the case of injury chart from the fine people at CBS Sports.

numberFire Tuesday Injury Update: Preseason Week Four

Injured Player: other options the Cleveland Browns have offensively, they will not rush Richardson back from an injury too soon. If he's limited or completely out in week one against the Eagles (and their young LB corps), that opens the door for Montario Hardesty to play the role of featured back. However, I wouldn't trust Hardesty with carrying the ball to the ref after the coin toss, let alone in an actual game. In 9 games played and 4 started last season, Hardesty averaged just barely over three yards per carry and didn't score a single rushing touchdown on the season. His advanced numbers look even more Cleveland Browns-esque, with an unusually high -0.38 NEP per rush (meaning that every time he rushed the ball, the Browns lost 0.38 net expected points when compared to the average team) and only a 20% success rate in helping his team have a better chance to score.
Verdict: Don't pick up

Injured Player: Scott can be a useful back-up to the Law Firm. Despite him not being a factor in fantasy directly as a back-up like won a job on Saturday, although not necessarily the #3 job. Don't be surprised if he wins of Jerry Jones's heart by the time September 5th rolls around.
Verdict: Potential pickup, Keep an eye on the situation

Injured Player: RBs ahead of schedule, but with the type of injury that one expert said could keep him out until October, I don't see the Chargers rushing him back right away if he shows any sign of soreness. Enter Ronnie Brown. Despite only hitting the 30 year-old mark last season, Brown's numbers have seen a decline for the past couple of years. His past two NEP per rush marks (-0.15 in 2011, -0.20 in 2010) are his worst two totals of his seven year career, and his 29% success rate in 2010 was one of the worst among starting backs. Even if he does play, I don't expect much from Brown; I just expect Philip Rivers to air it out some more.
Verdict: Don't pick him up