The Buffalo Bills notched a statement win in Week 1, and they can make another statement tonight against the Tennessee Titans, last year's top seed in the AFC.

On FanDuel Sportsbook, the Bills are 10.0-point home favorites in a game with a 47.5-point total. That makes the implied score 28.75-18.75 in favor of the Bills.

For those unfamiliar, single-game slates feature five flex spots with identical scoring to the main slate. However, kickers are included in these contests, and there is an "MVP" roster slot. The MVP receives 1.5-times his total fantasy points, making this spot crucial.

Our Brandon Gdula has done a deep dive on single-game strategy, and we have projections for the single-game slate if you select the game from the slate tab. It's worth checking out both of those things before you make your lineups.

MVP Candidates

While our model projects six players for double-digit FanDuel points, there's one clear-cut top option for MVP -- Josh Allen ($17,500 on FanDuel).

Allen projects for 24.5 FanDuel points, a whopping 6.2 more than anyone else. When he's at his best, which he was last week in a 33.48-point explosion, Allen is a fantasy cheat code who is capable of finishing drives by plowing through defenders at the goal line or by launching 50-yard touchdown passes. He's a monster, and he's definitely the player most likely to lead this single-game slate in scoring. The lone negative is that he'll surely be mega-chalk at MVP.

Derrick Henry ($15,000), Stefon Diggs ($14,000) and Ryan Tannehill ($14,500) are all projected for at least 14.1 FanDuel points. I won't venture outside of these three and Allen at MVP. While none of this trio has the floor/ceiling combination Allen does, they also won't be nearly as popular of an MVP as he is.

Henry is the most intriguing of the bunch to me. In a lot of ways, this is a bad spot for him. The Titans are 10.0-point road 'dogs, and Henry usually cedes passing-game work to other backs. He's also facing a Bills' defense that gave up the 12th-fewest FanDuel points per game to running backs (19.1) last year and looked really great in Week 1. I think you can make a strong case for fading Henry altogether -- not just at MVP.

But we know Henry has an incredible single-game ceiling and is capable of massive outings. Plus, he might not wind up being a very popular MVP play if the masses flock to Allen. Jonathan Taylor nuked this Buffalo run D a year ago, and Dontrell Hilliard -- who ran as the Titans' pass-catching back in Week 1 -- has been ruled out. The best route for Tennesee to win this game likely involves riding Henry and keeping Allen on the sideline. We project Henry for 18.3 FanDuel points, and I like him as an MVP pivot off Allen if you want to get a little weird but not too weird.

Diggs makes a ton of sense as a stacking partner with Allen, and if Gabriel Davis ($12,500) sits, Diggs could be extra busy. He was excellent in Week 1, catching 8-of-9 targets for 122 and a touchdown. We have him going for 15.2 FanDuel points.

Lastly, there is Tannehill. He has nowhere near the upside of Allen, but he might be the fourth-most popular MVP play. We should always be intrigued by any signal-caller who isn't going to be a popular MVP, but with that said, it's hard to see him popping off against this Bills D unless he runs a lot and/or gets some flukey touchdown luck. We project Tannehill for 14.1 FanDuel points.

Flex Breakdown

The status of Davis is a key thing to watch. If Davis plays, he's projected for 10.6 FanDuel points, per our numbers, and is a quality flex option. If Davis sits, it likely pushes more looks to Dawson Knox ($9,000) and Isaiah McKenzie ($7,500), and it opens a lot of snaps as Davis led Buffalo's wideouts with a 98.3% snap rate in Week 1.

McKenzie generated some hype this offseason but ended up having a quiet Week 1 despite a touchdown, totaling 2 grabs for 19 yards. He played only 43.1% of the snaps, a number that will surely rise if Davis sits. Knox was in on 86.2% of Buffalo's plays last week, so he's viable regardless of Davis' status. He mustered a mere one target in Week 1, catching it for five yards. He'll have better days if the snap rate stays high, and he is pegged to score 6.4 FanDuel points tonight, per our model, although our numbers account for Davis playing.

Jamison Crowder ($7,000) played just 31.0% of the snaps last week but would likely see a lot more run if Davis sits. Jake Kumerow ($5,000) would be on the dart-throw radar without Davis.

Bills running backs Devin Singletary ($10,500) and Zack Moss ($7,000) had Week 1 snap rates of 58.6% and 37.9%, respectively. James Cook ($6,500) played 5.1% of the snaps and was an afterthought. Singletary is projected for 10.0 FanDuel points and is the best of this bunch, but Tennessee permitted the fewest FanDuel points per game to running backs (16.1) last year.

On the Tennessee side, no one outside of Henry or Tannehill is projected for more than 9.0 FanDuel points. Receivers Robert Woods ($10,000) and Treylon Burks ($11,000) are the best of the rest, and they could see good volume in what's expected to be a negative game script.

Burks played just 36.7% of the snaps in Week 1 but got 5 targets, catching 3 for 55 yards. He has big-play chops, something that is always appealing on single-game slates. We have him at 6.7 FanDuel points. Woods was in on 68.3% of plays a week ago but got just 2 targets. Our algorithm projects the veteran to score 8.9 FanDuel points.

With Hilliard out, there's some pass-game work up for grabs for Tory Carter ($5,000), Hassan Haskins ($5,000) or Julius Chesnut ($5,000). Carter was the only one of this group to play a snap last week, but he didn't handle a single touch and was targeted just once. He looks like the best dart throw of the group. Tennessee might just let Henry play nearly every snap.

You can certainly make a case for the Buffalo D/ST ($9,000). They had a superb showing in Week 1, both in real life and fantasy (17.0 FanDuel points). That'll probably make them a pretty popular target tonight. We have them scoring 8.3 FanDuel points.

Our model projects Tyler Bass ($9,500) as the best point-per-dollar play among those with a salary under $14,000, giving him a projection of 8.3 FanDuel points.