Indianapolis Colts quarterback Andrew Luck (shoulder) has been ruled out for Week 5's game against the San Francisco 49ers.
Luck is participating in his first practice of the season on Wednesday, but he's not ready to return to full-speed action yet, and he'll be limited on the practice field today. Jacoby Brissett will draw at least one more start for the Colts.
numberFire's models don't account for Luck returning until Week 12, and we project him to go 121.5-for-207.2 with 1380.3 yards, 7.2 touchdowns and 7.1 interceptions on the year.
Source: Rotoworld.com