Salary: $6,500

Azpilicueta is tied with five other players as the seventh-highest priced defender on the slate, and he has averaged 16.62 FanDuel points per game through four matches. Azpilicueta has scored over 13 FanDuel points in every match so far this season, but has only exceeded the 16 point mark once -- 23.8 FanDuel points in Matchweek 2 against Arsenal.

Azpilicueta has averaged 2.25 tackles, 1.5 clearances, 1.5 interceptions and 1 blocked shot per 90 minutes this season and will now face a Cardiff City squad that should struggle to maintain possession and put pressure on the Blues' back line. Despite allowing the ninth-most clearances (4.71) per 90 minutes, the Bluebirds are near the bottom of the table in the other categories, allowing the third-fewest interceptions (0.97), third-fewest blocked shots (0.32) and fewest tackles (1.16) per 90 minutes to opposing defenders.

If DFS players are looking for a defender who gets involved in the attack, Watford's Jose Holebas ($7,000) should have that opportunity while offering what should be a decent floor against the Red Devils, while Azpilicueta offers only a floor without much upside.