Four of the teams on the slate played in the Champions League in midweek. Manchester City and Pep Guardiola are going full force for the title in the big European competition. Sergio Aguero ($12,500) is dealing with a foot injury, but he has the backing of the manager as the main offensive threat. However, a game against Cardiff City is a great time to rest your stars. Guardiola is known for his lineup rotation, and this game fits perfectly into that scheme so it wouldn't be shocking to see Aguero -- and other City mainstays -- rested.

The other teams may not rotate their lineups as much. Liverpool could make a change in midfield, with Naby Keita ($7,500) starting on the bench during the week. Roberto Firmino ($11,000) also started on the bench after sustaining an eye injury, but he came off the bench to score the winner.

Lucas Moura ($8,500) played only the last half hour on Tuesday, with Heung-min Son ($8,000) starting for Tottenham. Manchester United may be the least likely team to make changes, but make sure to check for potential roster rotation from all four clubs.