FanDuel Price: $5,400

Another running back getting a big chance, Spencer Ware is one of the top running back plays of the week, assuming Jamaal Charles is out on Sunday, which appears to be the likely scenario.

Ware was incredibly efficient when he saw the field last season. His 0.20 Rushing NEP per carry ranked second among the 72 running backs to see at least 50 carries.

The Chiefs have been a run-heavy team under coach Andy Reid -- even when Charles is out -- and their pass-to-run ratio made them the seventh-most run-heavy squad in the league in 2015. This is a great matchup for that rushing attack as the Chiefs are 7-point favorites against a San Diego Chargers team that ranked 31st in schedule-adjusted Rushing NEP per play last year.