Over/Under: 44.5
Bills Implied Team Total: 26.75
49ers Implied Team Total: 17.75

The over/under for this game isn't nearly as sexy, but that works for daily fantasy purposes because we don't have to target any San Francisco 49ers players anyway. Instead, let's focus on the Buffalo Bills, who have the fourth-highest implied team total on the slate, as well as the largest spread. The Bills should also benefit from a big step up in pace, as they rank second-to-last in offensive plays per game and take on the Niners, whose opponents have run the fourth-most plays this season.

LeSean McCoy, RB, Buffalo Bills

FanDuel Price: $8,200

LeSean McCoy continues to be a workhorse for the Bills, most recently turning 20 touches into 158 total yards last week against the Los Angeles Rams. He has averaged 6.1 yards per carry over his past three games, despite facing three tough run defenses, in the Rams, New England Patriots, and Arizona Cardinals. He finds himself in a much easier matchup this week against the Niners, who have allowed 4.4 yards per carry this season (seventh-worst). They have also been considerably worse on the road since the beginning of last season, allowing 155 rushing yards per game on the road, as opposed to 109 at home.

As mentioned with Miller, game script suggests that Shady would see a boost in his production as heavy favorites. That historical trend has carried true for McCoy, per the Rotoviz Game Splits App. Since the beginning of last season, he has averaged 0.6 more carries, 21.6 more rushing yards, and 2.5 more FanDuel points in games the Bills won.

Bills Defense

FanDuel Price: $4,800

Buffalo D/ST comes in as the third-most expensive unit on the slate -- and for good reason after posting three consecutive performances of at least 15 FanDuel points. This week, they draw the 49ers, whose 17.75-point implied team total ranks dead last on the slate. To make things even more exciting, they are throwing Colin Kaepernick back into the fire, listing him as the starting quarterback. Kap's most recent on-field heroics involve throwing 5 picks, fumbling 5 times, and taking 28 sacks in eight starts last season.

Buffalo's defense is an awesome standalone play this week and also correlates nicely with McCoy if you want to stack them.